The Dr. John Walter Parker Sr. House is a historic house at 1405 South Alabama Street in Pine Bluff, Arkansas. It is a single-story brick building, with a complex gabled roof line and a porch that curves from the front around to the left side. Built in 1909–10, it is believed to be one of the first brick houses in the community to be built for, and owned by, an African American. John Walker Parker, for whom it was built, was a dentist who opened his practice in Pine Bluff in 1905.